Polydeoxyribonucleotide(PDRN)

Polydeoxyribonucleotide (PDRN) is a chemical made up of many (that’s the “poly” part of the name) deoxyribonucleotides. Polydeoxyribonucleotide(PDRN) has dual antioxidant properties, and has anti-aging, hydration, soothing in skin care.

Product Name: Polydeoxyribonucleotide(PDRN)
INCI Name: Sodium DNA
Product Code: YNR®PDRN
CAS No.: 100403-24-5
Formula: Null
Functions: Anti-Aging, Hydration, Soothing,Antioxidant

product details

product description

Product Introduction

Polydeoxyribonucleotide (PDRN) is a chemical made up of many deoxyribonucleotides. Deoxyribonucleotides are the building blocks of DNA, the genetic material of all living organisms. The polynucleotides present in this ingredient are biocompatible with human skin, imparting visible repair, surface regeneration and soothing properties.

PDRN has dual antioxidant properties: it helps thwart oxidative damage from free radicals and, like superstar antioxidant glutathione, can increase skin’s supply of its own antioxidants, thus revving up its external defenses. It’s also been shown to help repair deeper damage to skin resulting from UV exposure.

Polydeoxyribonucleotide helps to fade hyperpigmentation when combined with vitamin C and niacinamide and delivered to skin via microneedling. Results were compared with using PDRN alone as well as gold standard ingredient hydroquinone, and the PDRN + vitamin C and niacinamide blend was on par with hydroquinone.

PDRN (polydeoxyribonucleotide) is a mixture of deoxyribonucleotides derived from Salmon, Trout or Chum Salmon sperm DNA through strict purification processes, which has high safety and stability. PDRN can activate the adenosine A2A receptors and also generate nucleotides that help the DNA synthesis, so that it has the functions of tissue repairing, wound healing and anti-aging. PDRN has been widely used in personal care products, mesotherapy, dermal fillers etc.

Sodium DNA is a signal peptide that mimics extracellular nucleotides. It is composed of DNA fragments from salmon sperm cells. The chemical structure consists of short, low molecular weight DNA chains, ranging from 50 to 1500 kiloDaltons in size. These DNA strands are polymers made up of linked deoxyribonucleotides, which are the building blocks of DNA. The deoxyribonucleotides contain a sugar, phosphate group, and purine or pyrimidine base.

The linear DNA chains twist together into the classic double helix shape. PDRN likely gets broken down by enzymes in the skin into individual nucleotides and nucleosides to provide benefits.

Key Technical Parameters

Appearance	White, light white or light yellow Powder
Assay(DNA Sodium)	90.0% min
Smell	Characteristic smell or tastelessness
Solubility	Slightly soluble in water
pH (1% Aqueous solution)	5.0~9.0
Molecular weight	1000Da max
Drying loss	20.0% max

At present, the application of PDRN in the field of skin mainly includes the following aspects:

Anti-aging: PDRN can remedy the damage to DNA and accelerate the repair of damaged cells by recycling and integrating bases and nucleosides. At the same time, PDRN can also supplement the bases required for DNA synthesis, promote wound healing, and accelerate cell metabolism.

Anti-inflammatory: PDRN can significantly inhibit inflammatory response, reduce symptoms such as redness, swelling, and pain of the skin, and can also inhibit the excessive occurrence of inflammatory response by regulating the expression of inflammatory factors. In addition, PDRN can also promote the production of anti-inflammatory factors and inhibit the release of pro-inflammatory factors.

Anti-oxidation: PDRN also has a certain antioxidant effect, which can effectively remove free radicals, reduce the damage of skin cells by free radicals, delay skin aging, improve skin condition, and prevent endogenous and exogenous aging of the skin.

Repair skin barrier: PDRN can promote the secretion of vascular endothelial growth factor (VEGF) and accelerate the migration, proliferation and angiogenesis of vascular endothelial cells. It can effectively improve the skin's microcirculation, provide more oxygen and nutrients to skin cells, accelerate the repair and regeneration of skin tissue, and promote the repair and reconstruction of the skin barrier.