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All About Isotretinoin---What You Should Know About This Acne Treatment
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All About Isotretinoin---What You Should Know About This Acne Treatment

2024-11-18
Isotretinoin works by reducing sebum (oil) production, stimulating cell turnover, and increasing the shedding of dead skin cells. This prevents the clogging of pores, which is often the main cause of acne.
Furthermore, isotretinoin has been shown to change the skin's microbiome so that it reflects that of someone who has normal skin. This can clear up existing acne, as well as prevent new acne from forming.
 
Isotretinoin works by targeting multiple factors that contribute to acne; it dramatically reduces the size and secretion of the sebaceous (oil) glands in the skin, normalizes the shedding of dead skin cells to prevent clogged pores, exhibits anti-inflammatory properties, and indirectly reduces populations of acne-causing bacteria.
 
What Does it Do?

Treats Severe Acne

One of the main benefits of Isotretinoin is its effectiveness in treating acne such as cystic and nodular acne that has not responded to other treatments. It reduces the size and secretion of the sebaceous glands, leading to a significant reduction in acne lesions. Treatment with Isotretinoin often leads to long-term clearance of acne. Many patients experience a permanent reduction in acne breakouts or a significant decrease in severity after a full course of treatment.

Prevents Acne Scarring

Isotretinoin reduces the number, size and severity of acne lesions. Since there are fewer severe acne lesions, such as cysts or nodules, this prevents or reduces acne scarring. Scars often form as a result of the body's attempt to heal severe inflammatory acne. So by treating the inflammation, Isotretinoin reduces the likelihood of this scarring.

Reduces Hyperpigmentation

Post-inflammatory hyperpigmentation (dark spots) can occur after acne heals, particularly in individuals with darker skin tones. While not scarring in the true sense, these marks can be as distressing as scars. Since Isotretinoin reduces inflammation and treats acne, this helps prevent dark spots from forming and keeps the skin tone more even.

Improves Overall Skin Texture & Rejuvenates Skin

By promoting proper skin cell turnover, Isotretinoin can improve the overall texture of the skin. It makes it smoother and less oily. Additionally, like all retinoids, Isotretinoin also stimulates your skin cells to produce more collagen. Firstly, this leads to smoother healing which improves the appearance of acne scars. It also helps treat signs of skin ageing like fine lines and wrinkles.

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How Does it Work?

Isotretinoin works using a multi-targeted approach which makes it a highly effective treatment for severe acne. This comprehensive action often results in long-lasting improvement, with many patients experiencing extended remission from acne after completing a course of Isotretinoin. Below is a little more detail about how Isotretinoin for acne works.

Reduces Sebum Production

Sebum is the oily substance that sebaceous glands produce. An excess of it can lead to clogged pores. Isotretinoin dramatically reduces the size and activity of the sebaceous glands. This leads to a significant decrease in sebum production. By doing so, it prevents the clogging of pores and the formation of acne.

Prevents Clogged Pores

Isotretinoin alters the life and growth cycle of skin cells. It promotes the shedding of dead skin cells and prevents them from clogging the pores. By keeping the pores clear, it reduces the chances of  blackheads and whiteheads forming. These are both precursors to more severe types of acne.

Anti-Inflammatory Effect

Acne often manifests with redness and swelling due to underlying inflammation. Isotretinoin has anti-inflammatory properties that reduces this inflammation. This calms the skin and speeds up the healing of existing acne lesions.

How Long Does Isotretinoin Treatment Typically Last?

Isotretinoin treatment duration may differ, but it generally lasts four to six months. The treatment course can be altered based on how the patient's skin reacts to the treatment and the occurrence of any side effects. In some cases, patients may need more than one course of treatment to get the desired outcomes.

How Soon Will You See Results From Isotretinoin Treatment?

The effectiveness of isotretinoin treatment for acne can vary from person to person. While some patients may start noticing improvements as early as one month into the treatment, others may take longer to see any visible changes.

It is important to note that in some cases, acne may initially appear worse before it starts to improve. Therefore, it is essential to give the treatment some time to work before expecting significant results. Typically, it takes four to six months for the full benefits of the treatment to become apparent. During this time, it is crucial to follow the prescribed dosage and maintain a healthy skincare routine to ensure the best possible outcome.

Can You Use Other Acne Treatments While on Isotretinoin?

It's important to consult a dermatologist before combining isotretinoin with other acne treatments. Due to its potency and range of effects, using other treatments, particularly those that are drying or abrasive, can increase the risk of severe skin irritation and other side effects. In many cases, isotretinoin is sufficient on its own to effectively treat severe acne.

How Should You Care for Your Skin While on Isotretinoin?

Skincare during isotretinoin treatment should focus on gentleness and hydration. Use a mild, non-abrasive cleanser and a good moisturizer to combat dryness. It's also important to use sunscreen regularly, as isotretinoin can increase skin sensitivity to sunlight. Avoiding waxing and other harsh skin treatments is recommended to prevent skin irritation.

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Side Effects of Isotretinoin

The most common side effects of isotretinoin include:1

♦ Red, cracked, and sore lips

♦ Dry skin, eyes, mouth, or nose

♦ Nosebleeds due to dry nasal passages

♦ Peeling skin, especially on the palms and soles

♦ Joint and muscle pain

♦ Temporary thinning of hair

Isotretinoin is the strongest and most effective acne medication available. It is so powerful that 50% of people who complete a course of isotretinoin will never need an acne treatment again. Isotretinoin is only prescribed for severe acne that does not respond to other treatments, as it is associated with a high risk of side effects. Most people who use it will experience dry skin and lips. Although rare, the drug is also linked to depression and suicidal thoughts.

Using isotretinoin when pregnant will result in birth defects. If you do choose to take this drug, you will need to use two forms of birth control or abstain from sex until your course is complete. If you have any questions about isotretinoin, talk to your dermatologist.