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Hesperidin is a flavanone glycoside (flavonoid) found abundantly in citrus fruits. Its aglycone form is called hesperetin. Hesperidin is believed to play a role in plant defense. Hesperidin has antioxidant, anti-nflammatory, hypolipidemic, vasoprotective and anticarcinogenic and cholesterol lowering actions. Hesperidin can inhibit following enzymes: Phospholipase A2, lipoxygenase, HMG CoA reductase and cyclo-oxygenase. Hesperidins improve the health of capillaries by reducing the capillary permeability. Hesperidin are used to reduce hay fever and other allergic conditions by inhibiting the release of histamine from mast cells. The possible anti cancer activity of hesperidin could be explained by the inhibition of polyamine synthesis.
Also known as lemon peel extract or orange peel extract, hesperidin is a natural occurring flavonoid that occurs within citrus fruits (more specifically in the actual peels of lemons and oranges). In skin care, Hesperidin appears as either a white or colorless crystalline structure. Hesperidin can provide antioxidant and soothing properties that together contribute towards a brightened and improved skin appearance.
Hesperidin's antioxidant protection helps to neutralize free-radicals present in the environment. This helps to lower levels of reactive oxygen species found in the skin, which may work to promote skin radiance. When topically applied, hesperidin also exhibits a soothing effect and reinforces the skin's permeability barrier. As a result, skincare products, such as creams and ointments, often infuse hesperidin into formulation to help alleviate dry skin.
The Value of Hesperidin in the Cosmetics Industry:
•Anti-aging and skin barrier enhancement: Hesperidin is used in anti-aging products due to its antioxidant properties, helping to strengthen the skin barrier and protect the skin from environmental damage.
• Anti-UV damage: Hesperidin can effectively prevent UV-induced skin cell lipid peroxidation, thereby reducing erythema and UV damage to the skin.
•Whitening and depigmentation: Hesperidin exhibits whitening effects by inhibiting tyrosinase activity and melanin synthesis. Studies have shown that hesperidin can dose-dependently reduce tyrosinase activity and melanin content in melanocytes.
•Wound healing: Hesperidin has the potential to promote wound healing, which makes it promising for treating skin damage and accelerating recovery.
•Anti-inflammatory effects: Due to its anti-inflammatory properties, hesperidin can be used to treat inflammatory skin diseases such as acne.
•Prevention of skin cancer and other skin diseases: Hesperidin's anti-cancer properties make it a potential application value in preventing skin cancer and other skin diseases.
•Active ingredients in cosmetics: As a natural compound, hesperidin has good application prospects as an active ingredient in cosmetics due to its stability and low toxicity.
Sustainable skin care products: As a byproduct of orange peel, hesperidin meets the needs of sustainable skin care products and helps promote sustainable strategies based on the circular economy.