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Ophthalmic preservatives, such as polyquaternium-1 (PQ-1), are critical for the inhibition of growth of microbial contaminants in multi-dose bottles of topical medications. These antimicrobial agents must have a high efficacy against pathogenic organisms, while maintaining a favorable tolerability and safety profile.
Polyquaternium-1 is a type of Excipients which play a crucial role in the pharmaceutical industry as an essential category of active pharmaceutical ingredients (APIs). Polyquaternium-1 though not intended to have therapeutic effects themselves, are vital components that assist in formulating and manufacturing drugs.
Polyquaternium-1 is also called Polidronium chloride. It is amber to dark brown solid or solution, fairly hygroscopic; bland in taste and nonirritating. Have a large solubility in water, insoluble in ethanol, acetone or ethyl ether. Polyquaternium-1 is no obvious stimulation to the skin, not skin sensitization agent and revulsant, has good antibacterial properties; Polyquaternium-1 can be used as antiseptic for eye-drops as a kind of Ophthalmic preservatives.
Key Technical Parameters:
Applications:
♦ Ophthalmic preservatives
Advantages
● Hydrophilic
● Much large in size
● Leads to less cytotoxicity and ocular surface disease